i'm done with you

دیگه کارم باهات تمومه.
In general it's used to stress that the speaker doesn't wish to keep any relation with the person.
I'm tired of you. You never listen to me. Im disappointed you. And I've lost faith in you.
I don't want to deal with you anymore.

از دستت کلافه شدم

دیگه باهات کاری ندارم